MorphGear is basically a frontend. In order to use it you must download emulator modules. Available modules are a SNES module based on SNES9x, a PC-Engine / TurboGrafx 16 module based on Hu-Go!, and a Genesis module based on Generator. It is Easy to configure, has good compatibility, game play, graphics, and sound. Definitely worth a download.
(All components are now contained in a single download, simply extract and install the modules of your choice).